Prof Antonella Forlino


Antonella Forlino

University of Pavia

SCIENCE AREAS

Prof. Forlino's research activity is focused on the molecular, biochemical, and functional study of genetic diseases of the connective tissue, in particular Osteogenesis Imperfecta (OI) using in vitro and in vivo models.

She is interested in generating and characterizing Zebrafish models for the new OI forms and in using these models to identify targets for developing novel treatment. Her research is particularly focused on the effect of mutant collagen intracellular retention in bone cell homeostasis. Indeed she recently validated the zebrafish Chihuahua, carrying a mutation in the α chain of collagen type I, as model for osteogenesis imperfecta and demonstrated the efficacy of chemical chaperone treatment in ameliorating in vivo the bone phenotype.

INSTITUTION AFFILIATION

Prof. Antonella Forlino is Associate Professor of Biochemistry at the Department of Molecular Medicine, Unit of Biochemistry, University of Pavia. She has a PhD in Biochemistry and the Speciality in Genetics. She is a member of the Board of the PhD program in Biomedical Sciences at the University of Pavia.

ROLE IN BIOMEDAQU PROJECT

She is collaborating with Prof Eckhard addressing questions about dietary phosphorus requirements and how dietary phosphorus alters bone and tooth development in zebrafish models of osteogenesis imperfecta.

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